My wife has a 2009 Toyota Venza which is almost identical to a Lexus RX 300 as far as body shape. Here's a link to an RX http://www.lexus.com/models/RX/ as it shows a side view of how the roof rack sits. The Venza is the same dimensions within a couple centimeters.
It's got a long sloping windshield which moves the two bars on the roof rack pretty far back. The lift gate on the back as got a little spoiler on top it with the brake light in it.
I tried to see how my Thule ski box would fit and placed it on the roof rack. The bars line up exactly right but it sits pretty far back. If I were to put it on, you could only get the lift gate open about 1/3 of the way. You could barely get bags in and out and you'd have to duck way under the gate to even try.
The only way I could see the ski box fitting without getting in the way of the lift gate would be if I drilled new holes in it and mounted it about one foot forward. I don't think that's a very good idea was it would be way out of balance and the front would stick forward and catch air off the windshield. Both could put undo stress on the roof rack bars. Don't want the thing to get ripped off the roof when traveling 65MPH on the interstate.
Anyone have a ski box solution for such a vehicle?
I really like my Thule ski box. It's got tons of stickers on it too!