|Fat people produce more estrogen than skinny people. That goes for males too.
That's an interesting point you bring up, Nolo.
Although estrogen certainly impinges upon brain circuitry involved in feeding behavior and metabolism, it is not clear how estrogen modulates these neuronal pathways.
There are seemingly a bazillion hormones/factors involved in regulating feeding and body weight, and that's just in rodents. Estrogen may be an important member of this group, but since feeding and weight gain are context specific, its role is most likely limited.
Estrogen is elevated in many obese patients, but is estrogen an obligate player driving the obesity or is it secondary? Other studies, in contrast, demonstrated that estrogen deficiency
results in an obesity syndrome, suggesting that the hormone functions to down regulate body weight.