While HACE and HAPE can be symptomatically treated (ie generalized edema, pulmonary edema, N/V, headache) Diamox is not a cure. the only cure for AMS is to get down the mountain and into a lower altitude. Tolerable hypoxia can occur at 14,000 ft.
But if you experience more severe signs/symptoms like blurred vision, confusion, a productive cough (thats when you are actually coughing up fluid), extreme fatigue, extreme SOB, severe headache, or N/V you need to get down FAST. HACE is not something that commonly occurs above 18,000ft. but some people are just more sensitive to it and it has very little to do with your level of fitness. You could be a cardio mack daddy comparable to Lance Armstrong or Ed Veistures, but once you get hit with HACE or HAPE you really dont want to mess with it.
Acclimation is a good idea. Alcohol is not and if you are on Diamox or Lasix or any other diuretic you really need to amp up on hydration. You dont want to end up dehydrated, that will only skyrocket your BP and give you a killer headache.
Have fun but, be carefull and aware of what's happening internally as well as outside.