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Glucosamine and chondroitin sulfate in knee injury rehabilitation. - Page 4

post #91 of 94
Originally Posted by exracer View Post
Copied from a news release I just read:

Researchers from the Department of Orthopedic Surgery at the University of Southern California, Los Angeles, have conducted a review of the scientific literature to determine the effectiveness of glucosamine and chondroitin sulfate in knee osteoarthritis (OA).

The reviewers critically evaluated the published clinical studies on glucosamine and chondroitin sulfate’s use in osteoarthritis. After examining the literature, they found that almost every included trial confirmed that the safety of these compounds was equal to the placebo. In the studies satisfying the scientists’ inclusion criteria, glucosamine sulfate, glucosamine hydrochloride, and chondroitin sulfate have individually shown inconsistent efficacy in decreasing osteoarthritis pain and improving joint function. However, when the substances were given together, many studies confirmed osteoarthritis pain relief with glucosamine and chondroitin sulfate use.

These findings led the reviewers to conclude, “The excellent safety profile of glucosamine and chondroitin sulfate therapy should be discussed with patients, and these supplements may serve a role as an initial treatment modality for many OA patients.”

Vangsness CT Jr, Spiker W, Erickson J. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis. Arthroscopy. 2009 Jan;25(1):86-94.
Rock on.
post #92 of 94


Originally Posted by exracer View Post


I've been taking Glucosamine Sulfate for over 20 years as part of my ongoing nutritional program. The supplement cured the stiffness I was developing in my hands years ago, and I have had no joint problems whatsoever since, so I would have to say it has worked for me. It is also a natural anti-inflammatory. It will take about 8 weeks before you will begin to see any benefits in the short term, but the real benefit is its value for long term maintenance and prevention of future joint and arthritis problems. As they say, "An ounce of prevention..."

Clinical studies in Europe have shown that a daily dosage of 1500 mg is sufficient to provide a therapeutic effect (Europe is waaaay ahead of North America when it comes to qualifying effective pharmaceutical and nutritional treatments). In many cases, studies have also shown that not only can Glucosamine Sulfate combat, but it can actually reverse, the effects of osteoarthritis. Taken as a part of an ongoing preventative health regimen, it is a component and regulator in the synthesis of proteoglycans, which are a building block of cartilage. It also helps prevent the degradation of cartilage over time.

Some products combine Chondroitin Sulfate with Glucosamine, but there is little clinical evidence that this produces any additional benefit over Glucosamine alone because most studies have used high molecular weight Chondroitin Sulphate. Although Chondroitin Sulfate is a component of cartilage, it has a molecular weight of as high as 50,000 Daltons (depending on the source) which prevents it from being absorbed through the G.I. tract. The good news is that your body can easily fabricate its own Chondroitin through available precursors, so supplemental Chondroitin is not only non-absorbable, in most cases, but also unnecessary.

If you're going to use a product that contains Chondroitin Sulfate, look for one that specifically states that it is low molecular weight Chondroitin Sulphate (18,000 Daltons or less) otherwise there is absolutely no way it will have any effect and you will be throwing your money away. Chondroitin Sulfate is available in several forms, and ranges in molecular weight from around 5,000 - 50,000 Daltons. As I previously stated, most product available off the shelf is on the higher end of the scale (because it's cheaper) and is therefore completely useless. The body can't absorb it. Any of the double blind tests that have hinted at the positive effect of Condroitin Sulfate supplementation have specifically used the low molecular weight form. All other studies have shown no effect when higher molecular weight Condroitin Sulfate is used.

So the lesson here is that taking a Chondroitin Sulfate supplement may or may not benefit you, but taking Glucosamine Sulfate will help in all cases.

MSM is also a very effective supplement to support joint health, as are antioxidants such as proanthocyanadins (grape seed extract) which block the enzyme responsible for degrading cartilage, and curcumin, which is strongly anti-inflammatory. Because they all work in a different manner, the best approach is to use them all if it's within your budget. Personally I use Glucosamine Sulphate, Grape Seed Extract, and Curcumin daily. I don't use Chondroitin Sulphate because I know my body can manufacture what it needs from my diet.

The interesting thing is that veterinary medicine is light years ahead when it comes to testing, formulating, and proving the efficacy of nutritional supplementation. When it comes to human health, however, the FDA controls us and the FDA is pretty much controlled by the drug companies who don't want you to know there are many nutritional alternatives that are far superior to drugs when it comes to your health. If they can't make a buck off it through patents, then they don't want you to know about it or have access to it.

For anyone interested, here's a link to an interesting article that summarizes a number of double blind research studies that have proven the efficacy of Glucosamine Sulphate and low molecular weight Chondroitin Sulphate. Glucosamine & Chondroitin Research


I need to start looking into this for hip pain that is atarting to affect a lot of what I do, including sleeping.

post #93 of 94

I like the liquid, I keep it in the fridge and take a sip every morning. It's miracle juice for me. www.flexicose.com.

post #94 of 94

I like the liquid. I keep it in the fridge and take a sip every morning. It's miracle juice for me. www.flexicose.com

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