Seattle has lots of business/finance, law, and advertising activity. A great deal of biotech and health activity as well - which might be able to translate into pharma sales. Nearby ski areas range from 45 min to a few hours away.
Sadly, this year sucked for skiing. In general though, the area is a winner for skiing (alpine & nordic), kayaking (ww & touring), hiking - just about any outdoor activity. The only bad news is that the cost of housing is pretty nasty here too. Not as bad as the Bay Area, but lots of folks are not all that happy when they see the cost of a house.
Also, to be honest, Seattle has become sort of an odd place socially over time. It is universally regarded as a very polite town. However, it has started to get a reputation as a somewhat cold place in terms of meeting people. I think this is even more the case on the East Side. The Seattle Times ran an article about this a couple months ago.
Still, the town has lots of amenities - and it is tough to beat a major city where you can skip town early in the morning, ski a bunch, and, if you want, easily be home for an early dinner (or in time to pick kids up fron school). Weekday lift lines are about 15 seconds long. Weekend lift lines can be bad in Jan and early Feb.
I live on the East Side, but like the politcial climate in Seattle better. Seattle proper is as Blue as it gets. The East Side (Bellevue, Redomond, Kirkland, etc) has been Red-ish, but is drifting toward purple over time. In general, you get more house for your money on the East Side. Because of Microsoft, the commute out of Seattle is worse than commuting into downtown. Overall, traffic sucks though. Almost as bad as the Bay Area - maybe as bad. However, you are also closer to skiing. Especially on the East Side. Issaquah is about 20 minutes to Snoqualmie. You can usually get from Redmond or Woodinville to Stevens Pass in less than an hour and a half. Crystal is a couple hours or so, depending on where you live (although it always seems to take me longer). Baker is about 3 hours.
The climate is more variable than most people from other places think. Some years are very moderate in terms of rain and temp. Others can drive you nuts. Lots of snow variability as well. I knew some folks who moved up here a few years ago. Their first summer and winter were really nice. They wondered why Seattle had a bad rap for being so rainy and cold. The next fall/winter we had 90 days straight of rain. They moved back to CA. Seriously. Bad winters (or summers) you just have be be OK chasing the sun somewhere else. Or skiing