I live in Santa Fe and have made many road trips to Wolf Creek. Albuquerque airport to Santa Fe is about 50 minutes and from my door in Santa Fe I can get to the parking lot in Wolf Creek in about 2.5 hours (3 if the roads are slow). That's taking route 84 up through Pagosa Springs and then the 160 east to WC. So figure 3.5 - 4 hours from ABQ. There's also an alternate route taking route 285 north (still passing through Santa Fe from ABQ), and approaching Wolf Creek from the east via Alamosa, CO. Yet another route (25 to 44 to 537 to 64 to 84) bypasses Santa Fe and takes you from ABQ through several Indian reservations, including the Jicarilla Apache reservation. I haven't gone this route but I know that the tribal police can be really tough on speeding cars and the going will probably be slower. Anyway you go the scenery is quite beautiful but the going will be slow (50-60mph) on the lesser highways. Watch out for elk if you're driving at night and be sure to check the Wolf Creek website for road conditions prior to departure. Sometimes they close the Wolf Creek pass (or require chains/4WD) when there's heavy snow:
If the Wolf Creek pass is closed, you'd have to come in from the east, via the 285 route.
I would also highly recommend stopping and soaking in Pagosa Springs on the way back, perfect ending for a day (or more) of skiing.