Well I know the closest place to Reno that USAirways flies is either San Fran or Vegas. I'm pretty sure that United flies direct to Reno, and if that doesn't work they also fly to Sacramento. But I'm guessing it would take atleast two stops to get you there. changing over in either Philly or Pitt and then having to fly to San Fran before flying to Reno.
To arrive in the area from Rochester with only one stop (Chicago) on United, you would have to fly to Sacramento (SMF). This would leave you a 2-hour drive (120 miles) to either North shore (I-80) or South shore (US-50). You may find airfares are less going in to SMF and overall trip time is significantly less than indirect to Reno via Pittsburgh and Denver. BTW travel distance from Reno to the lake is only 48 to 55 miles depending on the shore. The Sacramento option also leaves you an option for a day trip to the Bay Area (180 miles from Tahoe) if you want a break on the way out.