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Glucosamine - Page 2

post #31 of 39
How you doing, hey, can you clean off the windshield for me, haha! can't see a thing! Hey Ryel,My wifes been taking it for a while now and it seems to be helping her cope with bad knees and joints, etc. The long term cost is quite a bit though, might as well pay for Viox or celebrex and take care of the aches and pains.
post #32 of 39
Thread Starter 
<BLOCKQUOTE>quote:</font><HR>Originally posted by Lars:
My wifes been taking it for a while now and it seems to be helping her cope with bad knees and joints, etc. <HR></BLOCKQUOTE>

Glad to hear your favorite nurse is feeling fine. Maybe you can talk her into joining you next time out? Keep you from big air and other fancy stuff! Ha
post #33 of 39
This tread is very interesting because being an asthmatic, I cannot take aspirin or aspirin based drugs, tried it, very bad…very bad. I have to stick with Tylenol, does ok with pain but not with inflammation, I have to ice my knees at the end of the day. I have only fairly bad knees (too much volleyball and bumps as a young’n) I have tried shark cartilage without success, I will try glucosamine during this season and see if it makes a difference.

I’m no doc, but just from life experiences I have to agree with the thought that drugs (prescription or alternative) may not work for everyone, but you will never know if you don’t try it.
post #34 of 39
I've done some checking around this morning. So far what I have found there's no side effects. There is still some question though. it seems it does its job while taking it but the symptoms return when you stop unless your problem wa a temporary one. i.e. Bad headache, take aspirin or the like, stop taking it, the headache returns.
As I said before- if it works for you, great!
Something else I saw. A lot of these things, glucosamine might be included or might not, get into the stomach. The stomach acids destroy it. That's why many things are injected; to get by this problem. Another thing mentioned is the problem that people think 'have bone problems? take something with bone. Have cartilege problems? take something with cartilege' Unfortunately it doesn't work that way. That's just hardcore medical fact.
It seems years ago some guy was selling some kind of cartilege remedy. it was all the rage. So many people swore by it. Come to find out, it didn't do a dang thing. It was made out of chicken cartilege!
So far it seems glucosamine doesn't cure anything, but it relieves the pain. That may be help enough years down the road in lessening the deterioration of the joints! Neat! Hopefully that's the case.
post #35 of 39
For your reading pleasure, five decent studies on glucosamine:

1-In a recent study from 2000, 57 patients with osteoarthritis in the knee were treated randomly for four weeks with glucosamine sulfate intravenously combined with an 800 mg of chondroitin sulfate daily, or with a placebo. A record was kept of their knee pain, whether at rest, standing, or moving. No reduction of symptoms occurred with the placebo group, but the glucosamine/chondroitin sulfate group showed a great reduction of symptoms in all activity/nonactivity functions. This latter group also showed no negative reactions or any change in their blood tests. The study concluded that glucosamine sulfate is safe for long-term osteoarthritis treatment.

2-Another osteoarthritis study of the knee, in 1999 at the University of Liege in Belgium, involved 212 patients worldwide. These patients were randomly given either glucosamine or a placebo for three years. Parameters included both subjective and objective measurements. The patients' pain was measured every four months and x-rays were taken of their knees. The placebo group had more pain and narrowed joints, while the glucosamine group had no narrowing of joints and their condition improved. This was one of the first studies to show how glucosamine works by stopping the joints from narrowing. It was also one of the the first truly long-term studies conducted on glucosamine.

3-Harvard Medical School conducted a somewhat unorthodox study where patients scheduled for hip surgery were given ground chicken bone supplements. After two weeks of taking these supplements, their pain was reduced considerably. This study was noteworthy because of where it was done.

4-"Glucosamine is most effective in treating osteoarthritis, the most prevalent type of arthritis." A number of studies over the last 20 years have shown this. For example, a 1982 clinical study compared the usage of the NSAID ibuprofen with glucosamine sulfate, for osteoarthritis of the knee. During the first two weeks, ibuprofen decreased pain faster, but by the fourth week the glucosamine group was well ahead in pain relief. The overall results showed 44% of the glucosamine group had pain relief compared to 15% for ibuprofen. Because glucosamine is not an anti-inflammatory drug, it takes longer to start working, but it works equally well.

5-Another study from the 1980's with 252 doctors and 1,506 patients conducted in Portugal provided good clinical information on appropriate dosage and usage of glucosamine sulfate for osteoarthritis. For 50 days, patients took 500 mg of glucosamine sulfate three times a day. The results showed 95% of the patients benefited from the supplement, as it reduced their pain whether they were resting, standing, or exercising. This study also showed the effects of glucosamine on obese patients, however, they may require higher dosages to offset the joints' reaction to the stress from obesity. Those patients also taking diuretics or suffering from peptic ulcers were also studied regarding the effect of, and their tolerance to, glucosamine. The former might require higher dosages and the latter need to take glucosamine with food.

Anyone else have any other studies of note?

post #36 of 39
Very impressive. what were the conclusions? Great relief for pain, so far. Great! You speak as though I'm against this. All I said was I'm still deciding. btw- a fandom population to be significant should be in the thousands not 50 or 60 or 200. You mentioned injections. Great! With injections it may do wonders. I merely choose not to jump on the band wagon of every fad that comes along, that's all.

Here's some things which may be interesting.

Dr. Dean: To my knowledge, we have not seen detriment, except that people might ignore a torn ligament or something like that. So I can’t see anything bad. I’m keeping an open mind on it.

Some of these supplements are just worthless…they’re either worthless, or harmful, or there is no evidence of any positive effect at all. With this particular one there is enough interest in evidence that it might be helpful, but the studies I’ve seen are talking in a league of like an aspirin, in terms of relief of pain.

But they’re supposed to be able to help you grow new cartilage. Well, it’s not as simple as eat bones and you get strong bones, or eat cartilage and you can grow new cartilage. It’s not that simple.

Dr. Dean: To my knowledge, we have not seen detriment, except that people might ignore a torn ligament or something like that. So I can’t see anything bad. I’m keeping an open mind on it. Dr. Dean Edell

The major problem with glucosamine in my mind is the stomach acid factor. Whe you swallow something, you know, your stomach just breaks it down –- the acid hits it and digestive enzymes hit it –- and you don’t get any benefit from the supplement you are taking because of this.

People think they just swallow something. And if that were the case, we wouldn’t have injections; we wouldn’t have to inject people with anything. So some of these things, even though it might make sense when you swallow them, they’re destroyed by the stomach. So there are a lot of criticisms of the glucosamine studies.

I’d rather people do the right things to prevent injury rather than this stuff. You’ll hear all kinds of things; it’s impossible –- you cannot listen to people’s personal experiences about anything. That’s an anecdote and it supposedly went out in the 19th century, but of course, it’s more alive today than every before. - This is in response to a dance teacher who asked about glucosamine.

On the other hand-

We don't know if glucosamine will prevent the development of arthritis, but it may well be worth a try. It does not appear to provoke serious side effects or interact with most medications.

Chondroitin is more controversial. Most of the research showing its benefit for arthritis patients has used injectable chondroitin; it is not absorbed well from the digestive tract. There is very little information available on side effects, and the combination of glucosamine and chondroitin has not been thoroughly investigated.

"Thoroughly" is the operative word here!
Notice I am trying to present both sides of the issue here. Glucosamine looks very promising. Perhaps no better than other pain relievers, but then, what if someone is allergic to other pain relievers? Glucosamine may be the answer.

Glucosamine and chondroitin- There was some question as to cholesterol level increse. There is no scientific evidence to this yet, but there have been many reports that htis happened. But htis may be just a cause and effect situation. We don't know other contributing factors in these persons health make up. Too many varibles.

See? Both sides!

But then if you find your cholesterol go up, try this-

Guggul is derived from the resin of an Indian tree. It lowers total cholesterol and triglycerides and raises beneficial HDL cholesterol. Some people are allergic to this herb, however, so please be cautious.

Again both sides.

So far it's a great pain reliever, not a cure, doesn't rebuild cartilege. Most likely no side effects.

I still sit on the fence, leaning toward your side. I have nothing against it. Time is the best proof.

And above all, if this works for you, by all means take it! If it relieves the pain it may be helping in the long run. Just as Aleve or equivalents keep down swelling, it may lessen the effects of arthritis when we are older. Pain and swelling can do so much damage. Taking Aleve and /or glucosamine may help us way down the road.

For crying out loud... if I see you in pani and you are out of glucosamine, I'll go to the store and get it for you! I'm not against it, I just choose to reserve final judgement for myself taking it. Sheesh!
post #37 of 39
question- Does glucosamine work better for upper or lower extremeties or does it seem to help everywhere? it seems it would be helpful at all joints.
post #38 of 39
It helps my shoulders, hips and knees. A lady in my office says it helps her hands and wrists.
post #39 of 39
If it helps, that's great!
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