Recommendation would be I-70 for both options.
As long as the drive is not happening on a weekend morning, I-70 should be faster and easier.
A little less than half of the drive, Glenwood to Ridgway, is in high desert and will have adverse weather VERY rarely. You get to stay on expressway with 65 mph+ speed limits until S of Montrose.
This is a long damn drive either way, but the I-70 route requires less active driving.
US 285 is prettier, but it is exhausting doing Denver to Durango- and from there you still have 2 1/2 hours to go (about 9 all told). Most of this drive is rural highway with 2 lanes (1 each way) and no shoulder. Most of this drive is in the snow zone. The road in South Park and San Luis Valley doesn't stay snowpacked unless the storm just recently passed, but it is very easy for winds to create white-outs by blowing snow in the valleys across the road.
You have several more passes to negotiate going this way. Many are not really that big of a deal, but you should expect Wolf to be snowpacked and a bit hairy. If you have any qualms about driving mountain passes in winter (with a rental car?) go the other way.
If a meaningful part of your trip is putting eyes on other ski areas, I-70 is the way to go. You drive past/through Loveland, Copper, Vail, Beaver Creek, and you can glimpse Breck from the tunnel downgrade, and Keystone in your rearview around Silverthorne.
The US 285 route, you will drive by Wolf Creek, and Hesperus, and nobody cares about these places.